Relationship between jumping abilities and skeletal muscle architecture of lower limbs in humans: Systematic review and meta-analysis.

No procede.The aim of this study was to examine the influence of skeletal muscle architecture (SMA) features measured by 2-D ultrasonography on jumping performance in humans. A systematic review and meta-analysis was conducted, registry number: CRD42016043602. The scientific literature was systematically searched in eight databases, last run on March 14th, 2017. Cross-sectional studies focused on the association between SMA features and vertical jumping performance were selected. A random-effects model was used to analyze the influence of lower-limb SMA and maximal jump height. A total of 11 studies were included in the qualitative synthesis and 6 studies were selected for meta-analysis. 250 correlations were reviewed across studies. The vast majority were either not statistically significant (185; 74%), weak or very weak (169; 68%) for different jump modalities; counter-movement jump (CMJ), squat jump (SJ), and drop jump. There was insufficient data to perform meta-analysis on muscles other than vastus lateralis for CMJ and SJ. The meta-analyses did not yield any significant association between vastus lateralis SMA and SJ height. Only a significant overall association was shown between vastus lateralis thickness and CMJ height (summary-r = 0.28; 95% confidence interval (CI) = -0.05 to 0.48; p = .059) for a 90% CI level. No differences were found between summary-r coefficients for SMA parameters and jump height during both jumps (CMJ: χ2 = 2.43; df   = 2; p = .30; SJ: χ2 = 0.45; df = 2; p = .80) with a low heterogeneity ratio. Current evidence does not suggest a great influence of lower-limb SMA on vertical jumping performance in humans.No.Actividad Física y DeporteTerapia y Rehabilitació

Evaluation of the alkalinity stress tolerance of three Brassica rapa CAX1 TILLING mutants

Alkalinity is an important environmental factor that affects crop production and will be exacerbated in the current climate change scenario. Thus, the presence of carbonates and high pH in soils negatively impacts nutrient assimilation and photosynthesis and causes oxidative stress. A potential strategy to improve tolerance to alkalinity could be the modification of cation exchanger (CAX) activity, given that these transporters are involved in calcium (Ca2+) signaling under stresses. In this study, we used three Brassica rapa mutants (BraA. cax1a-4, BraA.cax1a-7, and BraA.cax1a-12) from the parental line ‘R-o-18’ that were generated by Targeting Induced Local Lesions in Genomes (TILLING) and grown under control and alkaline conditions. The objective was to assess the tolerance of these mutants to alkalinity stress. Biomass, nutrient accumulation, oxidative stress, and photosynthesis parameters were analyzed. The results showed that BraA.cax1a-7 mutation was negative for alkalinity tolerance because it reduced plant biomass, increased oxidative stress, partially inhibited antioxidant response, and lowered photosynthesis performance. Conversely, the BraA.cax1a-12 mutation increased plant biomass and Ca2+ accumulation, reduced oxidative stress, and improved antioxidant response and photosynthesis performance. Hence, this study identifies BraA.cax1a-12 as a useful CAX1 mutation to enhance the tolerance of plants grown under alkaline conditions.Plan Propio de Investigación y Transferencia, University of Granada awarde

Elementos, recursos y capacidades de las unidades de producción agrícola: desde un enfoque analítico reflexivo

The article discusses the elements, resources and capacities of agricultural production units. Based on the reflexive analytical approach of classical and current theoretical benchmarks. A Subjective interpretation is proposed as a central point to provide tools that contribute to the identification and configuration of elements of a system, resources with what works and organizational capabilities, leading to competitive advantages and interdependence relationships of companies. The findings show that agricultural production units will need to implement strategies to achieve levels of growth that help overcome gaps and problems of hunger and poverty in the world.El artículo analiza los elementos, recursos y capacidades de las unidades de producción agrícola, partiendo del enfoque analítico reflexivo de referentes teóricos disciplinares clásicos y actuales. Se propone una interpretación subjetiva como punto central para brindar herramientas que contribuyan a la identificación y configuración de elementos de un sistema, recursos con los que funcionan y capacidades organizacionales, derivando en ventajas competitivas y relaciones de interdependencia de las empresas. Los hallazgos evidencian que las unidades de producción agrícola deberán implementar estrategias que permitan alcanzar niveles de crecimiento que coadyuven a superar brechas y problemas de hambre y pobreza en el mundo

Tomografía computarizada a nivel de C3 y dinamometría como técnicas de diagnóstico de sarcopenia en pacientes con cáncer de cabeza y cuello

Introduction: A pilot study that tried to diagnosis sarcopenia by computed tomography (CT) at the third cervical vertebra (C3) and dynamometry in head and neck cancer patients. Comparison of the muscle mass (MM) determined by CT, with classical anthropometric measure and dynamometry techniques.Material and methods: MM and adipose tissue were analyzed by CT at C3 level in 37 oncological patients using Hounsfield Units (HU). Consequently, skeletal muscle index (SMI) and handgrip was determined for the diagnosis of sarcopenia. Finally, SMI was compared by classical anthropometric techniques, as well as by dynamometry.Results: 59.46% of the sample presented a decreased SMI (cm2/m2), 64.86% dynapenia, 54.05% sarcopenia, and 32.43% sarcopenic obesity. On the other hand, mean intermuscular adipose tissue was 6.69 (3.8) cm2, and mean intramuscular adipose tissue 2.06 (1.11) cm2.  In addition, a statistically significant association was found between SMI and strength in strong hand (estimate = 0.412, 95% CI [0.219, 0.605], p-value <0.001) and in the weak hand (estimate = 0.289, IC95% [0.123, 0.454], p-value <0.001). Regarding the branchial muscle circumference, we did not reach to demonstrate a positive correlation.Conclusions: Our study indicates that in head and neck cancer patients there is a high prevalence of sarcopenia. In addition, muscle depletion assessed by CT scans and dynamometry have demonstrate positive correlation, and consequently, those patients with greater muscle depletion at the C3 level have less muscle functionality.Introducción: Estudio piloto que determina el diagnóstico de sarcopenia mediante tomografía computarizada (TC) a nivel de la tercera vértebra cervical (C3) y dinamometría en pacientes con cáncer de cabeza y cuello. Comparación de la masa magra (MM) determinada mediante TC con técnicas clásicas de antropometría y dinamometría.Material y métodos: Se analizó la MM y el tejido adiposo mediante TC a nivel de C3 en 37 pacientes oncológicos mediante Unidades Hounsfield (UH). Posteriormente, se calculó el índice musculoesquelético (IME) y se determinó la fuerza prensora de mano para la determinación de sarcopenia. Por último, se comparó el IME mediante técnicas de valoración antropométrica clásica y dinamometría. Resultados: El 59,46% de los pacientes presentaron un IME (cm2/m2) disminuido, el 64,86% dinapenia, el 54,05% sarcopenia, el 32,43% sarcopenia dentro del sobrepeso y obesidad.  Por otro lado, la media de la masa grasa intermuscular fue 6,69 (3,8) cm2, y la masa grasa intramuscular 2,06 (1,11) cm2. Además, se encontró una asociación estadísticamente significativa entre la fuerza tanto en la mano fuerte (estimado = 0,412, IC95% [0,219; 0,605], p-valor <0,001) como en la mano débil (estimado =0,289, IC95% [0,123; 0,454], p-valor <0,001) y el IME cm2/m2. Respecto a la circunferencia muscular braquial), no alcanzamos a mostrar correlación positiva.Conclusiones: Nuestro estudio muestra que en el paciente con cáncer de cabeza y cuello la prevalencia de sarcopenia es elevada. Además, la depleción muscular evaluada mediante TC a nivel de C3 y dinamometría presenta cierta correlación, por lo que, aquellos pacientes con mayor depleción muscular a nivel de C3 presentan menor funcionalidad

A Fast 0.5 T Prepolarizer Module for Preclinical Magnetic Resonance Imaging

We present a magnet and high power electronics for Prepolarized Magnetic Resonance Imaging (PMRI) in a home-made, special-purpose preclinical system designed for simultaneous visualization of hard and soft biological tissues. The sensitivity of MRI systems grows with field strength, but so do their costs. PMRI can boost the signal-to-noise ratio (SNR) in affordable low-field scanners by means of a long and strong magnetic pulse. However, this must be rapidly switched off prior to the imaging pulse sequence, in timescales shorter than the spin relaxation (or T1) time of the sample. We have operated our prepolarizer at up to 0.5 T and demonstrated enhanced magnetization, image SNR and tissue contrast with PMRI of tap water, an ex vivo mouse brain and food samples. These have T1 times ranging from hundreds of milli-seconds to single seconds, while the preliminary high-power electronics setup employed in this work can switch off the prepolarization field in tens of milli-seconds. In order to make this system suitable for solid-state matter and hard tissues, which feature T1 times as short as 10 ms, we are developing new electronics which can cut switching times to ~ 300 μs. This does not require changes in the prepolarizer module, opening the door to the first experimental demonstration of PMRI on hard biological tissues

Evaluación del sexismo ambivalente en las y los profesionales de la red de salud mental de Andalucía. Resultados preliminares

Una línea de investigación clave actualmente en Psicología es el estudio del constructo sexismo que aparece relacionado con factores de riesgo psicosocial y de salud en población femenina general. El objetivo de nuestra investigación se dirige al análisis del sexismo ambivalente (hostil y benévolo) en profesionales de salud mental pública de Andalucía mediante un estudio correlacional en una muestra de 945 profesionales, analizando la relación entre sexismo ambivalente y algunas características sociodemográficas, laborales y profesionales. Los resultados mostraron puntuaciones bastantes bajas en sexismo (inferiores a las encontradas en otros estudios) así como diferencias de género significativas tanto en sexismo hostil como benévolo, siendo más sexistas los hombres. De todas las profesiones de la red de salud mental, la Psicología Clínica se mostró como la menos sexista. No se encontraron diferencias significativas en sexismo en función del Modelo Teórico, salvo en quienes usaron Perspectiva de Género, que aparecieron como menos sexistas. Se encontró que a mayor sexismo menor detección de problemas relacionados con la desigualdad de género en la consulta, pero no se encontró relación entre sexismo y formación recibida en Perspectiva de Género.A currently very important line of research in psychology is about Ambivalent Sexism (that has two sub-components: hostile sexism –SH- and benevolent sexism –SB-). This construct appears related to health and psychosocial risk factors in the general female population. This research aims to investigate the relationship between the ambivalent sexism and some features of the professionals of mental health in Andalusia. Using a correlational methodology, we examined the relationship between sexism and some socio-demographic and labor characteristics of 415 professionals working in public mental health services in Andalusia. The results showed that scores in both types of sexism were quite low (less than those found in other studies), and significant differences were found between men and women in sexism (men scored higher on both types of sexism). Of all the network of mental health professions, clinical psychology seems the less sexist. No significant differences were found in sexism depending on the theoretical model (c-behavioural, psychoanalysis, systemic…), except with those who adopted a gender perspective, which appeared as less sexist. Finally, sexism was negatively related to the detection of problems associated with gender in the consultation, but not with training in gender issues

Estudio transversal de medición de la composición corporal en pacientes con cáncer mediante antropometría y técnicas de imagen médica

Introduction: The main purpose of this study was to diagnose body composition in cancer patients before starting radiotherapy treatment, by using classic techniques based on anthropometry and biochemical parameters, as well as including new techniques based on computed tomography (TC) images.Material and methods: A sample of 22 patients with cancers that affect the digestive system underwent radiotherapy computed simulation which included measurements at L3 regions. Body composition was determined by using classic anthropometry, biochemical parameters and skeletal muscle mass by using Hounsfield Units (HU).Results: Mean BMI was 65,19 (±12,72) Kg, mean BMI 23,74 (± 5,03) kg/m2, mean average of WL 15,84 (±10,87) %, mean triceps skinfolds 9,73 (± 5,08) mm and mean brachial muscle perimeter 22,81 (± 2,95) cm. In terms of lab analysis, hipoalbumin was present in 63.45% of patients. On the other hand, according to body composition measured by CT scan, patients presented a mean waist circumference 99,06 (±13,38) cm, mean MM 119,41 (±35,54) cm2, and mean SMI 71,50 (±20.57) cm2/m2; being under normal cut points in 13,64% of patients.Conclusion: New techniques based on CT scans could be daily incorporated into clinical practice in cancer patients as an additional information of classic anthropometry and biochemical parameters, being a simple technique to perform, with low cost, reproducible and very reliable in terms of determination of body composition.Introducción: Analizar la composición corporal tanto mediante técnicas antropométricas y parámetros bioquímicos clásicos, como mediante técnicas modernas utilizando tomografía computarizada (TC), en pacientes oncológicos antes de iniciar el tratamiento con radioterapia.Metodología: Se analizaron de forma retrospectiva 22 pacientes con diversos tumores del aparato digestivo, que fueron sometidos al TC de planificación antes de iniciar el tratamiento con radioterapia, y que disponían de un corte axial en la tercera vértebra lumbar. Para analizar la composición corporal, se determinaron tanto parámetros antropométricos y bioquímicos clásicos, como la determinación de la masa muscular mediante Unidades Hounsfield (UH).Resultados: En cuanto a las características antropométricas clásicas, el peso medio fue 65,19 (±12,72) Kg, IMC 23,74 (± 5,03) kg/m2, %pp 15,84 (±10,87) %, PT 9,73 (± 5,08) mm y CMB 22,81 (± 2,95) cm. En cuanto a los parámetros bioquímicos, la hipoalbuminemia estuvo presente en el 63,45% de los casos. Por otro lado, la medición de composición corporal mediante técnicas modernas, determinó un promedio de circunferencia de cintura de 99,06 (±13,38) cm, MM de 119,41 (±35,54) cm2, y la media del IME fue de 71,50 (±20.57) cm2/m2; estando por debajo de la normalidad en el 13,64% de los pacientes.Conclusiones: Las nuevas técnicas por imagen basadas en cortes TC, pueden incluirse en la rutina diaria del paciente oncológico como información adicional a los parámetros antropométricos y bioquímicos más clásicos, por ser una técnica sencilla de realizar, con bajo coste, reproducible y muy fiable en cuanto a determinación de composición corporal

Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner

[EN] Magnetic Resonance Imaging (MRI) of hard biological tissues is challenging due to the fleeting lifetime and low strength of their response to resonant stimuli, especially at low magnetic fields. Consequently, the impact of MRI on some medical applications, such as dentistry, continues to be limited. Here, we present three-dimensional reconstructions of ex-vivo human teeth, as well as a rabbit head and part of a cow femur, all obtained at a field strength of 260 mT. These images are the first featuring soft and hard tissues simultaneously at sub-Tesla fields, and they have been acquired in a home-made, special-purpose, pre-medical MRI scanner designed with the goal of demonstrating dental imaging at low field settings. We encode spatial information with two pulse sequences: Pointwise-Encoding Time reduction with Radial Acquisition and a new sequence we have called Double Radial Non-Stop Spin Echo, which we find to perform better than the former. For image reconstruction we employ Algebraic Reconstruction Techniques (ART) as well as standard Fourier methods. An analysis of the resulting images shows that ART reconstructions exhibit a higher signal-to-noise ratio with a more homogeneous noise distribution.We thank anonymous donors for their tooth samples, Andrew Webb and Thomas O'Reilly (LUMC) for discussions on hardware and pulse sequences, and Antonio Tristan (UVa) for information on reconstruction techniques. This work was supported by the European Commission under Grants 737180 (FET-OPEN: HISTO-MRI) and 481 (ATTRACT: DentMRI). Action co-financed by the European Union through the Programa Operativo del Fondo Europeo de Desarrollo Regional (FEDER) of the Comunitat Valenciana 2014-2020 (IDIFEDER/2018/022). Santiago Aja-Fernandez acknowledges Ministerio de Ciencia e Innovacion of Spain for research grant RTI2018-094569-B-I00.Algarín-Guisado, JM.; Díaz-Caballero, E.; Borreguero-Morata, J.; Galve, F.; Grau-Ruiz, D.; Rigla, JP.; Bosch-Esteve, R.... (2020). Simultaneous imaging of hard and soft biological tissues in a low-field dental MRI scanner. Scientific Reports. 10(1):1-14. https://doi.org/10.1038/s41598-020-78456-2S114101Haacke, E. M. et al. Magnetic Resonance Imaging: Physical Principles and Sequence Design Vol. 82 (Wiley-liss, New York, 1999).Bercovich, E. & Javitt, M. C. Medical imaging: from roentgen to the digital revolution, and beyond. Rambam Maimonides Med. J. 9, e0034. https://doi.org/10.5041/rmmj.10355 (2018).Mastrogiacomo, S., Dou, W., Jansen, J. A. & Walboomers, X. F. Magnetic resonance imaging of hard tissues and hard tissue engineered bio-substitutes. Mol. Imag. Biol. 21, 1003–1019. https://doi.org/10.1007/s11307-019-01345-2 (2019).Duer, M. J. Introduction to Solid-State NMR Spectroscopy (Blackwell, Oxford, 2004).Oatridge, A. et al. Magnetic resonance: magic angle imaging of the achilles tendon. Lancet 358, 1610–1611. https://doi.org/10.1016/S0140-6736(01)06661-2 (2001).Funduk, N. et al. Composition and relaxation of the proton magnetization of human enamel and its contribution to the tooth NMR image. Magnetic Resonance Med.1, 66–75. https://doi.org/10.1002/mrm.1910010108 (1984).Schreiner, L. J. et al. Proton NMR spin grouping and exchange in dentin. Biophys. J . 59, 629–639. https://doi.org/10.1016/S0006-3495(91)82278-0 (1991).Niraj, L. K. et al. MRI in dentistry–a future towards radiation free imaging-systematic review. JCDRhttps://doi.org/10.7860/JCDR/2016/19435.8658 (2016).Shah, N. Recent advances in imaging technologies in dentistry. World J. Radiol. 6, 794. https://doi.org/10.4329/wjr.v6.i10.794 (2014).Newton, C. W., Hoen, M. M., Goodis, H. E., Johnson, B. R. & McClanahan, S. B. Identify and determine the metrics, hierarchy, and predictive value of all the parameters and/or methods used during endodontic diagnosis. J. Endodontics 35, 1635–1644. https://doi.org/10.1016/j.joen.2009.09.033 (2009).Brady, E., Mannocci, F., Brown, J., Wilson, R. & Patel, S. A comparison of cone beam computed tomography and periapical radiography for the detection of vertical root fractures in nonendodontically treated teeth. Int. Endod. J. 47, 735–746. https://doi.org/10.1111/iej.12209 (2014).Idiyatullin, D., Garwood, M., Gaalaas, L. & Nixdorf, D. R. Role of MRI for detecting micro cracks in teeth. Dentomaxillofac. Radiol. 45, 20160150. https://doi.org/10.1259/dmfr.20160150 (2016).Idiyatullin, D. et al. Dental magnetic resonance imaging: making the invisible visible. J. Endodontics 37, 745–752 (2011).Marques, J. P., Simonis, F. F. & Webb, A. G. Low-field MRI: an MR physics perspective. J. Magn. Reson. Imaging 49, 1528–1542. https://doi.org/10.1002/jmri.26637 (2019).Sarracanie, M. et al. Low-cost high-performance MRI. Sci. Rep. 5, 15177. https://doi.org/10.1038/srep15177 (2015).Weiger, M. et al. High-resolution ZTE imaging of human teeth. NMR Biomed. 25, 1144–1151. https://doi.org/10.5041/rmmj.103552 (2012).Grodzki, D. M., Jakob, P. M. & Heismann, B. Ultrashort echo time imaging using pointwise encoding time reduction with radial acquisition (PETRA). Magn. Reson. Med. 67, 510–518. https://doi.org/10.5041/rmmj.103553 (2012).Kaczmarz, S. Angenäherte auflösung von systemen linearer gleichungen. Bull. Int. Acad. Pol. Sci. Let., Cl. Sci. Math. Nat. 35, 355–357 (1937).Gordon, R., Bender, R. & Herman, G. T. Algebraic reconstruction techniques (ART) for three-dimensional electron microscopy and X-ray photography. J. Theor. Biol. 29, 471–481. https://doi.org/10.1016/0022-5193(70)90109-8 (1970).Gower, R. M. & Richtarik, P. Randomized iterative methods for linear systems. SIAM J. Matrix Anal. Appl.36, 1660–1690. 10.1137/15M1025487 (2015). arXiv:1506.03296.Ludwig, U. et al. Dental MRI using wireless intraoral coils. Sci. Rep.6, https://doi.org/10.1038/srep23301 (2016).Maggioni, M., Katkovnik, V., Egiazarian, K. & Foi, A. Nonlocal transform-domain filter for volumetric data denoising and reconstruction. IEEE Trans. Image Process. 22, 119–133. https://doi.org/10.5041/rmmj.103555 (2013).Weiger, M. & Pruessmann, K. P. Short-t2 mri: principles and recent advances. Prog. Nucl. Magn. Reson. Spectrosc. 114–115, 237–270 (2019).Jang, H., Wiens, C. N. & McMillan, A. B. Ramped hybrid encoding for improved ultrashort echo time imaging. Magn. Resonance Med. 76, 814–825 (2016).Wu, Y. et al. Water- and fat-suppressed proton projection mri (waspi) of rat femur bone. Magn. Reson. Med. 57, 554–567 (2007).Carr, H. Y. Steady-state free precession in nuclear magnetic resonance. Phys. Rev. 112, 1693–1701. https://doi.org/10.5041/rmmj.103556 (1958).Waugh, J. S., Huber, L. M. & Haeberlen, U. Approach to high-resolution NMR in solids. Phys. Rev. Lett. 20, 180–182. https://doi.org/10.5041/rmmj.103557 (1968).Waeber, A. M. et al. Pulse control protocols for preserving coherence in dipolar-coupled nuclear spin baths. Nat. Commun. 10, 1–9. https://doi.org/10.1038/s41467-019-11160-6 (2019).Frey, M. A. et al. Phosphorus-31 MRI of hard and soft solids using quadratic echo line-narrowing. Proc. Natl. Acad. Sci. U.S.A. 109, 5190–5195. https://doi.org/10.1073/pnas.1117293109 (2012).Galve, F., Alonso, J., Algarín, J. M. & Benlloch, J. M. Magnetic resonance imaging method with zero echo time and slice selection. ESP202030504 (2020).Cooley, C. Z. et al. A portable brain mri scanner for underserved settings and point-of-care imaging. arXiv2004.13183 (2020).Hills, B. P. & Clark, C. J. Quality Assessment of Horticultural Products by NMRhttps://doi.org/10.1016/S0066-4103(03)50002-3 (2003).Somers, A. E., Bastow, T. J., Burgar, M. I., Forsyth, M. & Hill, A. J. Quantifying rubber degradation using NMR. Polym. Degrad. Stab. 70, 31–37. https://doi.org/10.1007/s11307-019-01345-21 (2000).Tyler, D. J., Robson, M. D., Henkelman, R. M., Young, I. R. & Bydder, G. M. Magnetic resonance imaging with ultrashort TE (UTE) PULSE sequences: technical considerations. J. Magn. Reson. Imaging 25, 279–289. https://doi.org/10.1002/jmri.20851 (2007).Weiger, M., Pruessmann, K. P. & Hennel, F. MRI with zero echo time: hard versus sweep pulse excitation. Magn. Reson. Med. 66, 379–389. https://doi.org/10.1002/mrm.22799 (2011).Rahmer, J., Blume, U. & Börnert, P. Selective 3D ultrashort TE imaging: comparison of “dual-echo” acquisition and magnetization preparation for improving short-T2 contrast. Magn. Resonance Mater. Phys. Biol. Med.20, 83–92. https://doi.org/10.1007/s10334-007-0070-6 (2007).Rasche, V., Holz, D. & Schepper, W. Radial turbo spin echo imaging. Magn. Reson. Med. 32, 629–638 (1994).Fessler, J. A. On NUFFT-based gridding for non-Cartesian MRI. J. Magn. Reson. 188, 191–195. https://doi.org/10.1007/s11307-019-01345-24 (2007).Fessler, J. Model-based image reconstruction for MRI. In IEEE Signal Processing Magazine, vol. 27, 81–89, https://doi.org/10.1109/MSP.2010.936726(Institute of Electrical and Electronics Engineers Inc., 2010).Aja-Fernández, S. & Vegas-Sánchez-Ferrero, G. Statistical Analysis of Noise in MRI (Springer, Berlin, 2016).Aja-Fernández, S., Pieciak, T. & Vegas-Sánchez-Ferrero, G. Spatially variant noise estimation in MRI: a homomorphic approach. Med. Image Anal. 20, 184–197 (2015)

Discordance Between SARS-CoV-2-specific Cell-mediated and Antibody Responses Elicited by mRNA-1273 Vaccine in Kidney and Liver Transplant Recipients

Background: Severe acute respiratory syndrome coronavirus 2-specific cell-mediated immunity (SARS-CoV-2-CMI) elicited by mRNA-based vaccines in solid organ transplant (SOT) recipients and its correlation with antibody responses remain poorly characterized. Methods: We included 44 (28 kidney, 14 liver, and 2 double organ) recipients who received the full series of the mRNA-1273 vaccine. SARS-CoV-2-CMI was evaluated at baseline, before the second dose, and at 2 wk after completion of vaccination by an ELISpot-based interferon-γ FluoroSpot assay using overlapping peptides covering the S1 domain. SARS-CoV-2 immunoglobulin G seroconversion and serum neutralizing activity against the spike protein were assessed at the same points by commercial ELISA and an angiotensin-converting enzyme-2/spike antibody inhibition method, respectively. Postvaccination SARS-CoV-2-CMI was compared with 28 healthcare workers who received the BNT162b2 vaccine. Results: Positive SARS-CoV-2-CMI increased from 6.8% at baseline to 23.3% after the first mRNA-1273 dose and 59.5% after the completion of vaccination (P < 0.0001). Lower rates were observed for immunoglobulin G seroconversion (2.3%, 18.6%, and 57.1%, respectively) and neutralizing activity (2.3%, 11.6%, and 31.0%). There was a modest correlation between neutralizing titers and the magnitude of SARS-CoV-2-CMI (Spearman's rho: 0.375; P = 0.015). Fifteen recipients (35.7%) mounted SARS-CoV-2-CMI without detectable neutralizing activity, whereas 3 (7.1%) did the opposite, yielding poor categorical agreement (Kappa statistic: 0.201). Rates of positive SARS-CoV-2-CMI among SOT recipients were significantly decreased compared with nontransplant controls (82.1% and 100.0% after the first dose and completion of vaccination, respectively; P < 0.0001). Kidney transplantation, the use of tacrolimus and prednisone, and the number of immunosuppressive agents were associated with lower cell-mediated responses. Results remained unchanged when 3 recipients with prevaccination SARS-CoV-2-CMI were excluded. Conclusions: Two-thirds of SOT recipients mounted SARS-CoV-2-CMI following vaccination with mRNA-1273. Notable discordance was observed between vaccine-induced cell-mediated and neutralizing humoral immunities. Future studies should determine whether these patients with incomplete responses are effectively protected.This work was supported by the Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation (COVID-19 Research Call COV20/00181) and cofinanced by the European Development Regional Fund “A way to achieve Europe.” M.F.R. holds a research contract “Miguel Servet” (CP18/00073) and R.L.G. a research contract “Rio Hortega” (CM19/00120), both from the Instituto de Salud Carlos III, Spanish Ministry of Science and InnovationS